In the severe infected COVID-19 patients, besides the viral pneumonia, multi-organ/system injury could be observed. Recognizing and correcting the key and immediate dysfunctions may reduce the mortality.
Here, we report a male patient with severe SARS-CoV-2 infection from isolation Ward- Guanggu Branch of Hubei Province Maternity and Childcare Hospital, who is treated with combined inflammatory cytokines depletion therapy and convalescent plasma. The multi-modal therapy ultimately resulted in improvement of respiratory function and removal from mechanical ventilation. The case of ARDS with severe SARS-CoV-2 infection indicated the potential benefit of convalescent plasma and inflammatory cytokines depletion through combined measurements including double filtration plasma pheresis and Tocilizumab.
It is not safe to draw causal conclusions between cytokine depletion and clinical manifestations improvement with only one case, while this would be a potential research direction in facing the COVID-19 crisis.