Background During the COVID − 19 outbreak, limited medical resources in the short term and inadequate experience in dealing with major new public health events may lead to the neglect of some other infectious diseases, such as malaria, leading to the risk of the spread of infectious diseases.Therefore, it is particularly important to formulate classified guidance, take scientific prevention and control measures in a comprehensive manner, strengthen the screening of malaria patients and provide access to medical treatment during the outbreak. Methods Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for a falciparum malaria infection patient with laboratory-confirmed COVID − 19 pneumonia . Results Patient's serum novel coronavirus antibody tested positive for IgG and weakly positive for IgM that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2],the blood samples were classified as plasmodium falciparum by RT-PCR. Conclusions The patient when workers infected with p. falciparum in Africa, malaria recurrence after back to China, after antimalarial treatment in tianmen city first people's hospital, after an outbreak in wuhan will be coronavirus, and symptoms of COVID − 19, but soon be cured patients, to explore the diagnosis and treatment of antimalarial drugs in COVID − 19 patients with the role, for further in-depth study of COVID − 19 treatment provides a good example.