Aim: To investigate clinical characteristics, laboratory findings, and imaging features of patients confirmed with COVID-19 in Bushehr, a southern province of Iran. Method: During April 29th to May 30th 2020, a total of 148 patients confirmed with COVID-19 infection were admitted to three hospitals in Bushehr province, assigned by the Iranian Ministry of Health. Results: The most common coexisting disease was type 2 diabetes. Levels of ESR, CRP, LDH, and AST among inpatients were higher than the outpatients (P<0.05). There were significant differences in the levels of creatinine and BUN between elderly and non-elderly patients (P<0.05). Conclusion: Patients with comorbidities and elderly patients are at increased risk of severe progression of COVID-19.