Background: To date, only few studies have focused on the correlation between ABO blood groups and COVID-19 infection risk, especially gender differences in infection risk. Our study aimed to describe the ABO blood group distribution and its association with risk of severe COVID-19 infection for effective identification of the susceptible population.
Method：From January 21 to February 20, 2020, we compared the ABO blood group distribution and gender distribution and performed a correlation analysis in severe, non-severe, and non-COVID-19 patients.
Results The results showed that the laboratory indices were significantly different between blood type O and non-blood-type-O COVID-19 patients. This indicated that patients of the type O blood group had a relatively lower risk of severe COVID-19 infection than patients of other blood types; in particular, females with blood type O had a lower risk of severe COVID-19 infection than males.
Conclusion: Herein, we report a potentially simple prediction decision system to minimize the risk of severe COVID-19 infection based on blood type. Special attention should be paid to patients with blood types other than type O to minimize their risk of severe COVID-19 infection.